Monday, September 30, 2019

The Host Chapter 16: Assigned

The ledge of the rock exit was worn down, but it scraped my palms and shins as I scrambled through it. It hurt, stiff as I was, to wrench myself erect, and my breath caught. My head swam as the blood flowed downward. I looked for only one thing-where Jared was, so that I could put myself between him and his attackers. They all stood frozen in place, staring at me. Jared had his back to the wall, his hands balled into fists and held low. In front of him, Kyle was hunched over, clutching his stomach. Ian and a stranger flanked him a few feet back, their mouths open with shock. I took advantage of their surprise. In two long, shaky strides, I moved between Kyle and Jared. Kyle was the first to react. I was less than a foot from him, and his primary instinct was to shove me away. His hand struck my shoulder and heaved me toward the floor. Before I could fall, something caught my wrist and yanked me back to my feet. As soon as he realized what he'd done, Jared dropped my wrist like my skin was oozing acid. â€Å"Get back in there,† he roared at me. He shoved my shoulder, too, but it wasn't as hard as Kyle's push. It sent me staggering two feet back toward the hole in the wall. The hole was a black circle in the narrow hallway. Outside the small prison, the bigger cave looked just the same, only longer and taller, a tube rather than a bubble. A small lamp-powered by what, I couldn't guess-lit the hallway dimly from the ground. It cast strange shadows on the features of the men, turning them into scowling monster faces. I took a step toward them again, turning my back to Jared. â€Å"I'm what you want,† I said directly to Kyle. â€Å"Leave him alone.† No one said anything for a long second. â€Å"Tricky bugger,† Ian finally muttered, eyes wide with horror. â€Å"I said get back in there,† Jared hissed behind me. I turned halfway, not wanting Kyle out of my sight. â€Å"It's not your duty to protect me at your own expense.† Jared grimaced, one hand rising to push me back toward the cell again. I skipped out of the way; the motion moved me toward the ones who wanted to kill me. Ian grabbed my arms and pinned them behind me. I struggled instinctively, but he was very strong. He bent my joints too far back and I gasped. â€Å"Get your hands off her!† Jared shouted, charging. Kyle caught him and spun him around into a wrestling hold, forcing his neck forward. The other man grabbed one of Jared's thrashing arms. â€Å"Don't hurt him!† I screeched. I strained against the hands that imprisoned me. Jared's free elbow rammed into Kyle's stomach. Kyle gasped and lost his grip. Jared twisted away from his attackers and then lunged back, his fist connecting with Kyle's nose. Dark red blood spattered the wall and the lamp. â€Å"Finish it, Ian!† Kyle yelled. He put his head down and hurtled into Jared, throwing him into the other man. â€Å"No!† Jared and I cried at the same moment. Ian dropped my arms, and his hands wrapped around my throat, choking off my air. I clawed at his hands with my useless, stubby nails. He gripped me tighter, dragging my feet off the floor. It hurt-the strangling hands, the sudden panic of my lungs. It was agony. I writhed, more trying to escape the pain than the murdering hands. Click, click. I'd only heard the sound once before, but I recognized it. So did everyone else. They all froze, Ian with his hands locked hard on my neck. â€Å"Kyle, Ian, Brandt-back off!† Jeb barked. No one moved-just my hands, still clawing, and my feet, twitching in the air. Jared suddenly darted under Kyle's motionless arm and sprang at me. I saw his fist flying toward my face, and closed my eyes. A loud thwack sounded inches behind my head. Ian howled, and I dropped to the floor. I crumpled there at his feet, gasping. Jared retreated after an angry glance in my direction and went to stand at Jeb's elbow. â€Å"You're guests here, boys, and don't forget it,† Jeb growled. â€Å"I told you not to go looking for the girl. She's my guest, too, for the moment, and I don't take kindly to any of my guests killing any of the others.† â€Å"Jeb,† Ian moaned above me, his voice muffled by the hand held to his mouth. â€Å"Jeb. This is insane.† â€Å"What's your plan?† Kyle demanded. His face was smeared with blood, a violent, macabre sight. But there was no evidence of pain in his voice, only controlled and simmering anger. â€Å"We have a right to know. We have to decide whether this place is safe or if it's time to move on. So†¦ how long will you keep this thing as your pet? What will you do with it when you're finished playing God? All of us deserve to know the answers to these questions.† Kyle's extraordinary words echoed behind the pulse thudding in my head. Keep me as a pet? Jeb had called me his guest†¦ Was that another word for prisoner? Was it possible that two humans existed that did not demand either my death or my torture-wrung confession? If so, it was nothing less than a miracle. â€Å"Don't have your answers, Kyle,† Jeb said. â€Å"It's not up to me.† I doubted any other response Jeb could have given would have confused them more. All four men, Kyle, Ian, the one I didn't know, and even Jared, stared at him with shock. I still crouched gasping at Ian's feet, wishing there was some way I could climb back into my hole unnoticed. â€Å"Not up to you?† Kyle finally echoed, still disbelieving. â€Å"Who, then? If you're thinking of putting it to a vote, that's already been done. Ian, Brandt, and I are the duly designated appointees of the result.† Jeb shook his head-a tight movement that never took his eyes off the man in front of him. â€Å"It's not up for a vote. This is still my house.† â€Å"Who, then?† Kyle shouted. Jeb's eyes finally flickered-to another face and then back to Kyle. â€Å"It's Jared's decision.† Everyone, me included, shifted their eyes to stare at Jared. He gaped at Jeb, just as astonished as the rest, and then his teeth ground together with an audible sound. He threw a glare of pure hate in my direction. â€Å"Jared?† Kyle asked, facing Jeb again. â€Å"That makes no sense!† He was not in control of himself now, almost spluttering in rage. â€Å"He's more biased than anyone else! Why? How can he be rational about this?† â€Å"Jeb, I don't†¦Ã¢â‚¬  Jared muttered. â€Å"She's your responsibility, Jared,† Jeb said in a firm voice. â€Å"I'll help you out, of course, if there's any more trouble like this, and with keeping track of her and all that. But when it comes to making decisions, that's all yours.† He raised one hand when Kyle tried to protest again. â€Å"Look at it this way, Kyle. If somebody found your Jodi on a raid and brought her back here, would you want me or Doc or a vote deciding what we did with her?† â€Å"Jodi is dead,† Kyle hissed, blood spraying off his lips. He glared at me with much the same expression Jared had just used. â€Å"Well, if her body wandered in here, it would still be up to you. Would you want it any other way?† â€Å"The majority -â€Å" â€Å"My house, my rules,† Jeb interrupted harshly. â€Å"No more discussion on this. No more votes. No more execution attempts. You three spread the word-this is how it works from now on. New rule.† â€Å"Another one?† Ian muttered under his breath. Jeb ignored him. â€Å"If, unlikely as it may be, somehow this ever happens again, whoever the body belongs to makes the call.† Jeb poked the barrel of the gun toward Kyle, then jerked it a few inches toward the hall behind him. â€Å"Get out of here. I don't want to see you anywhere around this place again. You let everyone know that this corridor is off-limits. No one's got any reason for being here except Jared, and if I catch someone skulking around, I'm asking questions second. You got that? Move. Now.† He jabbed the gun at Kyle again. I was amazed that the three assassins immediately stalked back up the hallway, not even pausing to give me or Jeb a parting grimace. I deeply wanted to believe that the gun in Jeb's hands was a bluff. From the first time I'd seen him, Jeb had shown every outward appearance of kindness. He had not touched me once in violence; he had not even looked at me with recognizable hostility. Now it seemed that he was one of only two people here who meant me no harm. Jared might have fought to keep me alive, but it was plain that he was intensely conflicted about that decision. I sensed that he could change his mind at any time. From his expression, it was clear that part of him wanted this over with-especially now that Jeb had put the decision on his shoulders. While I made this analysis, Jared glowered at me with disgust in every line of his expression. However, as much as I wanted to believe that Jeb was bluffing, while I watched the three men disappear into the darkness away from me, it was obvious there was no way he could be. Under the front he presented, Jeb must have been just as deadly and cruel as the rest of them. If he hadn't used that gun in the past-used it to kill, not just to threaten-no one would have obeyed him this way. Desperate times, Melanie whispered. We can't afford to be kind in the world you've created. We're fugitives, an endangered species. Every choice is life-or-death. Shh. I don't have time for a debate. I need to focus. Jared was facing Jeb now, one hand held out in front of him, palm up, fingers curled limply. Now that the others were gone, their bodies slumped into a looser stance. Jeb was even grinning under his thick beard, as though he'd enjoyed the standoff at gunpoint. Strange human. â€Å"Please don't put this on me, Jeb,† Jared said. â€Å"Kyle is right about one thing-I can't make a rational decision.† â€Å"No one said you had to decide this second. She's not going anywhere.† Jeb glanced down at me, still grinning. The eye closest to me-the one Jared couldn't see-closed quickly and opened again. A wink. â€Å"Not after all the trouble she took to get here. You've got plenty of time to think it through.† â€Å"There's nothing to think through. Melanie is dead. But I can't-I can't-Jeb, I can't just†¦Ã¢â‚¬  Jared couldn't seem to finish the sentence. Tell him. I'm not ready to die right this second. â€Å"Don't think about it, then,† Jeb told him. â€Å"Maybe you'll figure something out later. Give it some time.† â€Å"What are we going to do with it? We can't keep watch on it round the clock.† Jeb shook his head. â€Å"That's exactly what we're going to have to do for a while. Things will calm down. Even Kyle can't preserve a murderous rage for more than a few weeks.† â€Å"A few weeks? We can't afford to play guard down here for a few weeks. We have other things -â€Å" â€Å"I know, I know.† Jeb sighed. â€Å"I'll figure something out.† â€Å"And that's only half the problem.† Jared looked at me again; a vein in his forehead pulsed. â€Å"Where do we keep it? It's not like we have a cell block.† Jeb smiled down at me. â€Å"You're not going to give us any trouble, now, are you?† I stared at him mutely. â€Å"Jeb,† Jared muttered, upset. â€Å"Oh, don't worry about her. First of all, we'll keep an eye on her. Secondly, she'd never be able to find her way out of here-she'd wander around lost until she ran into somebody. Which leads us to number three: she's not that stupid.† He raised one thick white eyebrow at me. â€Å"You're not going to go looking for Kyle or the rest of them, are you? I don't think any of them are very fond of you.† I just stared, wary of his easy, chatty tone. â€Å"I wish you wouldn't talk to it like that,† Jared muttered. â€Å"I was raised in a politer time, kid. I can't help myself.† Jeb put one hand on Jared's arm, patting lightly. â€Å"Look, you've had a full night. Let me take the next watch here. Get some sleep.† Jared seemed about to object, but then he looked at me again and his expression hardened. â€Å"Whatever you want, Jeb. And†¦ I don't-I won't accept responsibility for this thing. Kill it if you think that's best.† I flinched. Jared scowled at my reaction, then turned his back abruptly and walked the same way the others had gone. Jeb watched him go. While he was distracted, I crept back into my hole. I heard Jeb settle slowly to the ground beside the opening. He sighed and stretched, popping a few joints. After a few minutes, he started whistling quietly. It was a cheery tune. I curled myself around my bent knees, pressing my back into the farthest recess of the little cell. Tremors started at the small of my back and ran up and down my spine. My hands shook, and my teeth chattered softly together, despite the soggy heat. â€Å"Might as well lie down and get some sleep,† Jeb said, whether to me or to himself, I wasn't sure. â€Å"Tomorrow's bound to be a tough one.† The shivers passed after a time-maybe half an hour. When they were gone, I felt exhausted. I decided to take Jeb's advice. Though the floor felt even more uncomfortable than before, I was unconscious in seconds. The smell of food woke me. This time I was groggy and disoriented when I opened my eyes. An instinctive sense of panic had my hands trembling again before I was fully conscious. The same tray sat on the ground beside me, identical offerings on it. I could both see and hear Jeb. He sat in front of the cave in profile, looking straight ahead down the long round corridor and whistling softly. Driven by my fierce thirst, I sat up and grabbed the open bottle of water. â€Å"Morning,† Jeb said, nodding in my direction. I froze, my hand on the bottle, until he turned his head and started whistling again. Only now, not quite so desperately thirsty as before, did I notice the odd, unpleasant aftertaste to the water. It matched the acrid taste of the air, but it was slightly stronger. The tang lingered in my mouth, inescapable. I ate quickly, this time saving the soup for last. My stomach reacted more happily today, accepting the food with better grace. It barely gurgled. My body had other needs, though, now that the loudest ones had been sated. I looked around my dark, cramped hole. There weren't a lot of options visible. But I could barely contain my fear at the thought of speaking up and making a request, even of the bizarre but friendly Jeb. I rocked back and forth, debating. My hips ached from curving to the bowled shape of the cave. â€Å"Ahem,† Jeb said. He was looking at me again, his face a deeper color under the white hair than usual. â€Å"You've been stuck in here for a while,† he said. â€Å"You need to†¦ get out?† I nodded. â€Å"Don't mind a walk myself.† His voice was cheerful. He sprang to his feet with surprising agility. I crawled to the edge of my hole, staring out at him cautiously. â€Å"I'll show you our little washroom,† he continued. â€Å"Now, you should know that we're going to have to go through†¦ kind of the main plaza, so to speak. Don't worry. I think everyone will have gotten the message by now.† Unconsciously, he stroked the length of his gun. I tried to swallow. My bladder was so full it was a constant pain, impossible to ignore. But to parade right through the middle of the hive of angry killers? Couldn't he just bring me a bucket? He measured the panic in my eyes-watched the way I automatically shrank back farther into the hole-and his lips pursed in speculation. Then he turned and started walking down the dark hall. â€Å"Follow me,† he called back, not looking to see if I obeyed. I had one vivid flash of Kyle finding me here alone, and was after Jeb before a second passed, scrambling awkwardly through the opening and then hobbling along on my stiff legs as fast as I could to catch up. It felt both horrible and wonderful to stand straight again-the pain was sharp, but the relief was greater. I was close behind him when we reached the end of the hall; darkness loomed through the tall broken oval of the exit. I hesitated, looking back at the small lamp he'd left on the floor. It was the only light in the dark cave. Was I supposed to bring it? He heard me stop and turned to peer at me over his shoulder. I nodded toward the light, then looked back at him. â€Å"Leave it. I know my way.† He held out his free hand to me. â€Å"I'll guide you.† I stared at the hand for a long moment, and then, feeling the urgency in my bladder, I slowly put my hand on his palm, barely touching it-the way I would have touched a snake if for some reason I was ever forced to. Jeb led me through the blackness with sure, quick steps. The long tunnel was followed by a series of bewildering twists in opposing directions. As we rounded yet another sharp V in the path, I knew I was hopelessly turned around. I was sure this was on purpose, and the reason Jeb had left the lamp behind. He wouldn't want me knowing too much about how to find my way out of this labyrinth. I was curious as to how this place had come to be, how Jeb had found it, and how the others had wound up here. But I forced my lips tightly together. It seemed to me that keeping silent was my best bet now. What I was hoping for, I wasn't sure. A few more days of life? Just a cessation of pain? Was there anything else left? All I knew was that I wasn't ready to die, as I'd told Melanie before; my survival instinct was every bit as developed as the average human's. We turned another corner, and the first light reached us. Ahead, a tall, narrow crevice glowed with light from another room. This light was not artificial like the little lamp by my cave. It was too white, too pure. We couldn't move through the narrow fracture in the rock side by side. Jeb went first, towing me close behind. Once through-and able to see again-I pulled my hand out of Jeb's light grip. He didn't react in any way except to put his newly freed hand back on the gun. We were in a short tunnel, and a brighter light shone through a rough arched doorway. The walls were the same holey purple rock. I could hear voices now. They were low, less urgent than the last time I'd heard the babble of a human crowd. No one was expecting us today. I could only imagine what the response would be to my appearance with Jeb. My palms were cold and wet; my breath came in shallow gasps. I leaned as close as I could to Jeb without actually touching him. â€Å"Easy,† he murmured, not turning. â€Å"They're more afraid of you than you are of them.† I doubted that. And even if there were any way that it could be true, fear turned into hatred and violence in the human heart. â€Å"I won't let anybody hurt you,† Jeb mumbled as he reached the archway. â€Å"Anyway, might as well get used to this.† I wanted to ask what that meant, but he stepped through into the next room. I crept in after him, half a step behind, keeping myself hidden by his body as much as possible. The only thing harder than moving myself forward into that room was the thought of falling behind Jeb and being caught alone here. Sudden silence greeted our entrance. We were in the gigantic, bright cavern again, the one they'd first brought me to. How long ago was that? I had no idea. The ceiling was still too bright for me to make out exactly how it was lit. I hadn't noticed before, but the walls were not unbroken-dozens of irregular gaps opened to adjoining tunnels. Some of the openings were huge, others barely large enough for a man to fit through stooped over; some were natural crevices, others were, if not man-made, at least enhanced by someone's hands. Several people stared at us from the recesses of those crevices, frozen in the act of coming or going. More people were out in the open, their bodies caught in the middle of whatever movement our entrance had interrupted. One woman was bent in half, reaching for her shoelaces. A man's motionless arms hung in the air, raised to illustrate some point he'd been making to his companions. Another man wobbled, caught off balance in a sudden stop. His foot came down hard as he struggled to keep steady; the thud of its fall was the only sound in the vast space. It echoed through the room. It was fundamentally wrong for me to feel grateful to that hideous weapon in Jeb's hands†¦ but I did. I knew that without it we would probably have been attacked. These humans would not stop themselves from hurting Jeb if it meant they could get to me. Though we might be attacked despite the gun. Jeb could only shoot one of them at a time. The picture in my head had turned so grisly that I couldn't bear it. I tried to focus on my immediate surroundings, which were bad enough. Jeb paused for a moment, the gun held at his waist, pointing outward. He stared all around the room, seeming to lock his gaze one by one with each person in it. There were fewer than twenty here; it did not take long. When he was satisfied with his study, he headed for the left wall of the cavern. Blood thudding in my ears, I followed in his shadow. He did not walk directly across the cavern, instead keeping close to the curve of the wall. I wondered at his path until I noticed a large square of darker ground that took up the center of the floor-a very large space. No one stood on this darker ground. I was too frightened to do more than notice the anomaly; I didn't even guess at a reason. There were small movements as we circled the silent room. The bending woman straightened, twisting at the waist to watch us go. The gesturing man folded his arms across his chest. All eyes narrowed, and all faces tightened into expressions of rage. However, no one moved toward us, and no one spoke. Whatever Kyle and the others had told these people about their confrontation with Jeb, it seemed to have had the effect Jeb was hoping for. As we passed through the grove of human statues, I recognized Sharon and Maggie eyeing us from the wide mouth of one opening. Their expressions were blank, their eyes cold. They did not look at me, only Jeb. He ignored them. It felt like years later when we finally reached the far side of the cavern. Jeb headed for a medium-sized exit, black against the brightness of this room. The eyes on my back made my scalp tingle, but I didn't dare to look behind me. The humans were still silent, but I worried that they might follow. It was a relief to slip into the darkness of the new passageway. Jeb's hand touched my elbow to guide me, and I did not shrink away from it. The babble of voices didn't pick up again behind us. â€Å"That went better than I expected,† Jeb muttered as he steered me through the cave. His words surprised me, and I was glad I didn't know what he'd thought would happen. The ground sloped downward under my feet. Ahead, a dim light kept me from total blindness. â€Å"Bet you've never seen anything like my place here.† Jeb's voice was louder now, back to the chatty tone he'd used before. â€Å"It's really something, isn't it?† He paused briefly in case I might respond, and then went on. â€Å"Found this place back in the seventies. Well, it found me. I fell through the roof of the big room-probably shoulda died from the fall, but I'm too tough for my own good. Took me a while to find a way out. I was hungry enough to eat rock by the time I managed it. â€Å"I was the only one left on the ranch by then, so I didn't have anyone to show it to. I explored every nook and cranny, and I could see the possibilities. I decided this might be a good card to keep up my sleeve, just in case. That's how we Stryders are-we like to be prepared.† We passed the dim light-it came from a fist-sized hole in the ceiling, making a small circle of brightness on the floor. When it was behind us, I could see another spot of illumination far ahead. â€Å"You're probably curious as to how this all got here.† Another pause, shorter than the last. â€Å"I know I was. I did a little research. These are lava tubes-can you beat that? This used to be a volcano. Well, still is a volcano, I expect. Not quite dead, as you'll see in a bit. All these caves and holes are bubbles of air that got caught in the cooling lava. I've put quite a bit of work into it over the last few decades. Some of it was easy-connecting the tubes just took a little elbow grease. Other parts took more imagination. Did you see the ceiling in the big room? That took me years to get right.† I wanted to ask him how, but I couldn't bring myself to speak. Silence was safest. The floor began to slant downward at a steeper angle. The terrain was broken into rough steps, but they seemed secure enough. Jeb led me down them confidently. As we dropped lower and lower into the ground, the heat and humidity increased. I stiffened when I heard a babble of voices again, this time from ahead. Jeb patted my hand kindly. â€Å"You'll like this part-it's always everyone's favorite,† he promised. A wide, open arch shimmered with moving light. It was the same color as the light in the big room, pure and white, but it flickered at a strange dancing pace. Like everything else that I couldn't understand in this cavern, the light frightened me. â€Å"Here we are,† Jeb said enthusiastically, pulling me through the archway. â€Å"What do you think?†

Sunday, September 29, 2019

Maket Structure-Micromax

MARKET STRUCTURES What is a Market structure? In economics Market structure is the way the market is organized , based largely on the number of firms in the industry, number of buyers and levels of competition , for example Monopoly, oligopoly , Perfect Competition. Monopolistic competition is the market structure is the market structure I am going to base this assignment on. Monopolistic CompetitionMonopolistic Competition is a type of imperfect competition such that producers sell products that are differentiated from one another as goods but not as perfect substitutes, they differ in terms of brand, quality, and location. In monopolistic competition a firm takes the prices charged by its rivals as given and ignores the impact of its own prices of other firms. Monopolistic competition has the following Characteristics:- †¢ There are many producers and consumers in the market and no company has total control over the market price. There are very barriers in the entry & exit of firms. †¢ Producers have a degree of control over prices. †¢ There is product differentiation. †¢ Independent decision making. Examples of Monopolistic competition:- Firms involving the selling toothpastes, soaps, electronics, and automobiles are examples of monopolistic competition. ANALYSIS OF A COMPANY IN MONOPOLISTIC COMPETITION Company name: MICROMAX About Micromax Micromax is a consumer Electronics Company found in 1991 and based in Gurgaon, Haryana, India.It focuses primarily on the sale of Mobile phones, LED televisions as well as tablets. It has 23 domestic offices as well as offices in Honk Kong, Dubai, USA and also employs over 1400 employees. Micromax is the 3rd largest handset manufacturer and the 12th largest manufacturer in the world. As of 2012 , Micromax leads the Indian tablet market with a share of 18. 4% which is higher than even the likes of Apple and Samsung, it is also the 3rd largest mobile phone vendor in terms of volume.The company’s r apid market share growth since 2008 is primarily attributed to its aggressive low pricing and entry level segments of its products and its wide distribution setup. ANALYSIS OF A PRODUCT FROM MICROMAX Product name: MIcromax A116 Canvas HD The Micromas A116 Canvas HD was launched at the start of January 2013 and is the latest Smartphone to be launched by MIcromax and is also their best phone yet and aims to rival even the best Smartphones of international companies like Samsung, and Micromax has sought to do this with aggressive low pricing.Below are the specifications of the Micromax A116 HD |Screen and Resolution |5† HD(1280X720 pixels) | |Camera |8MP with LED flash & front facing camera | |RAM |1 GB | |Operating system |Android 4. Jelly bean | |Memory storage |4 GB, expandable to 32 GB | |Processor |1. 2 GHz quad core ARM cortex | |Battery |2,100 mAh Battery(approx 21 hours) |Overview The Micromax A116 Canvas HD has a plastic built and has a very powerful chipset and proc essor, and has no physical keys as it is a full touch screen. The Smartphone also comes with the latest operating system from Android which is Jellybean, the battery is a 2,100 mAh battery which will last for an approximate 21 hours. Price The Micromax A116 HD is priced at 15,000 Rupees. COMPETITION AND THEIR PRICESThe following tables are some competition from International Companies for Micromax:- Samsung |Samsung Galaxy Grand |21,500 | |Samsung Galaxy S3 |35,000 | |Samsung Galaxy S3 mini |24,000 |HTC |HTC One X |34000 | |HTC One S |22999 | |HTC One V |18000 |LG |LG Optimus G |35,000 | |LG Optimus L9 |19,899 | Nokia Nokia Lumia 620 |15,000 | |Nokia Lumia 920 |35,490 | |Nokia Lumia 900 |31,500 | The following are some competition from Domestic Companies for Micromax:- Karbonn Karbonn S1 Titanium |11,500 | ELASTICITY OF THE PRODUCT Price elasticity of Demand If the price of the product is increased by a particular amount, then the demand of the product will decrease by a fu rther amount, as the consumer has a host of other alternatives to choose from and will choose the item which will give him the most satisfaction at a lower cost, therefore the demand for these phones are highly elastic.Elasticity Of Supply If the Market price of the product decreases by a particular amount then the firm will supply fewer products than the amount in which the price has increased , as the firm does not want to sell their products at a lower price and will wait till the price increases to again increase their supply, therefore Micromax has an elastic supply. ———————– MONOPOLISTIC COMPETITION MARKET STRUCTURE RHYS CAMARA ROLL NUMBER -1 MARKET STRUCTURE

Saturday, September 28, 2019

Post Assignment Example | Topics and Well Written Essays - 500 words - 1

Post - Assignment Example This way, it will be possible to make accurate assumptions that will impact on planning positively because assumptions have influence on planning (Bush, 2005). I perfectly agree with the position you took on the purposes of EOP, especially when it comes to the aspect of planning. I would agree with you that planning is an important tool for achieving efficiency and for avoiding waste (Dudo, Dunwoody & Scheufele, 2011). Very often, emergency workers approach emergency events with virtually no idea about outcomes to expect. This happens when there is poor planning towards such events. Having an EOP can therefore help in ensuring that emergency workers abreast themselves with possibilities of emergency outcomes so that they can make the right preparations to them. An additional insight that I will like to add to your point is that whiles preparing emergency operations plans, it is important to take much inspiration from past events. I believe that it is based on past events that the right planning can be made to achieve efficiency. While you were opining on the questions/issues that must be addressed by an EOP, you made very important points which I agree with very perfectly. One of these was the point you made about the community. I agree with well that the community has a role to play in emergency management and that it is always very important to ask questions about the roles that the community can play in times of emergency. Once the role of the community is clearly defined, it will be possible to get the very best from them in times of emergency. The situation where community members interrupt the work of the emergency workers will also be avoided. This is because there will be distinctions between what they are allowed to do and what they are not allowed to you. With all the lessons above, it can be conclude

Friday, September 27, 2019

The Importance of Distinguishing Between Acquisition and Learning in Essay

The Importance of Distinguishing Between Acquisition and Learning in Second Language Performance - Essay Example Yet we are now seeing greater importance placed on these issues and in turn a better understanding of the multiple and varying difficulties that a student of second language acquisition can face. Differentiating between learning and acquisition signifies that these factors have a special place alongside that of the traditional problems of language learning. It is important to highlight on the word 'alongside' because differentiating between the two should not mean that either takes predominance or that there should be some kind of theoretical showdown, but rather that each term find its proper place and do its proper job. By taking into consideration both acquisition and learning and making a differentiation between the two we are better able to understand all sides of second language learning. To better understand the nature of the discussion around the manners with which we learn to speak a second language it is important to first define the terms we are using. First and foremost it should be noted that 'acquisition' and 'learning' aggregate significant meaning to the word language. Acquisition is defined as the act of acquiring or gaining something through one's own efforts and/or experience.1 Learning, on the other hand is defined as the act, process, or experience of gaining knowledge or skill, usually through schooling or studying.2 The term second language learning has traditionally been used to describe the process of learning a second language through formal instruction. For example, adults taking English classes are described as learning a language, not acquiring it. In Krashen's (1981) theory of second language performance he works with the distinction between acquisition and learning.3 Second language performance would be the term that encompasses the two independent systems, the acquired system and the learned system. The former is described as being the product of the human subconscious and entails meaningful interaction, while the later is the product of formal instruction and results in conscious knowledge of the language. In Krashen's input hypothesis he puts forth his theory on how one obtains the knowledge of a second language through language acquisition.4 He explains that an individual perks up along the natural order of learning a language. For example, if a learner is at a stage 'i', then acquisition takes place when he/she is exposed to 'Comprehensible Input' that belongs to level 'i + 1'. Different learners have different capacity and competence for seeking knowledge or absorbing new material. Since not all of the learners can be at the same level of linguistic competence at the same time, Krashen argues that natural communicative input is the key to designing a syllabus, ensuring in this way that each learner will receive some 'i + 1' input that is appropriate for his/her current stage of linguistic competence.5 Krashen's ground breaking work called to the forefront the long ignored area of psycholinguistics which focuses on the pivotal role feelings and sentiments play during the accumulation of a second language. At the core of his work is the belief that language acquisition does not require extensive use of conscious grammatical rules but rather meaningful interaction with the target language, what he calls a 'natural

Thursday, September 26, 2019

Virtual lab 3 Assignment Example | Topics and Well Written Essays - 250 words

Virtual lab 3 - Assignment Example However, if they grew independently, each would utilize the readily available natural resources and develop most favorable strength, leading to both surviving. On the tenth day, the Paramecium caudatum population reached the carrying capacity of the environment when grown alone. This is given that, subsequent to counting them repeatedly the number remained the same. On the fourth day, the Paramecium aurelia population reached the carrying capacity of the environment. This is given that, subsequent to the fourth day, the Paramecium Aurelia started dying out, whereas the others remained strong. When the two Paramecium species utilize the available food resources, then one of them has the likelihood of benefiting from more of the available resources over the other one, further leaving it to scramble for the fast depleting food (survival of the fittest). In this regard, the weak Paramecium species will lose the fight and die out. This will enable the strong one to grow strong to maturity while utilizing the readily available resources. Another observation entails the existence of chemical components that may lead to the death of one of the Paramecium species. Upon mixing the paramecium population in one test tube, one started dying out gradually. The other one attained its carrying capacity, further growing steadily leading to the death of the other

Wednesday, September 25, 2019

Budget and Performance Essay Example | Topics and Well Written Essays - 500 words

Budget and Performance - Essay Example This strategy is not in line with the values of its current business. Keeping all things into consideration, Guillermo makes the budgets and evaluate variances and takes corrective measures when and where required in order to run its business smoothly and efficiently. Every single businessman wants his business to run smoothly without any hindrance. In Guillermo's scenario, he manipulated the figures in order to make the business attractive, which is unethical. From Guillermo's accounting decision perspective, he manipulated the sales; the variable cost per unit and unit sales in order to attract the outside companies, like making the figures attractive for the Norwegian company. So it is very important for Guillermo not to take and adopt unethical values in his decision making because may be very good in the short-run but can prove disastrous for the company in the long run (Garrison, 2004).

Tuesday, September 24, 2019

Comment 2 Pick a War (View Point Aggresor Research Paper

Comment 2 Pick a War (View Point Aggresor - Research Paper Example However, Bulgaria was sceptical of Greece’s strengths and was concerned that Greece was on the brink of war with the Porte relative to dispute over Crete. In addition, the weaknesses implicit in the Ottomans particularly during the Italo-Turkish War motivated these states to look beyond their own issues with one another. Thus, in 1912 a defensive alliance was signed between Serbia and Bulgaria. Greece followed with a similar alliance with Sofia and Sofia followed by singing a similar agreement with Montenegro. As Hodge puts it, â€Å"Balkan states formed a network of alliances against Constantinople†.5 B. The primary that set off the shooting World powers became concerned about their interests in the region. For example, France was concerned that Russia would gain dominance in the Balkans. Austria-Hungary was particularly concerned about Serbia’s possible expansion since it sat on the southern border. As a result, Austria-Hungary appealed to other European powers to warn Balkan states not to upset the â€Å"balance of power.†6 Nevertheless, the Balkan League was convinced of their power and on 8 October 1912, Montenegro declared war on the Ottoman Empire. Four days later, the remaining states in the Balkan League would follow suit.7 Thus, the Balkan League was the aggressor in the Balkan War of 1912. C. Was the war legal when it happened? Would it be today? The applicable international instrument regulating the law of war at the time was the Hague Convention 1907. According to Article 1 of the 1907 Convention, states may not commence hostilities against one another unless an express advance notice is given â€Å"in the form of a declaration.†8 Since the war started with a declaration of war on the part of Montenegro which was followed by declarations by the remaining members of the Balkan League, the war was legal in 1912. However, today, the war would not be legal pursuant to the UN Charter in which various articles insist up on the peaceful settlement of disputes between states, forbid the use of military force and calls for respect of the integrity of sovereignty. The right to use force is only justified in defence of state sovereignty and generally where a threat is eminent.9 D. The Secondary Cause of War The seeds of discord leading to the first Balkan War were planted since the 1800s. At that time a wave of nationalism sweeping France and Germany filtered over into the Balkan Peninsular. Initially, the idea of nationalism in the Balkans centered around a demand for standardizing a Balkan language and thus emphasized a connection to a Balkan culture that predated the Ottomans. In the meantime, the nationalism movement in the Balkans took on a political tone. With nationalism taking on a political tone, there was a â€Å"strong desire to achieve national unity† which â€Å"motivated the Balkan states to confront their erstwhile Ottoman conquerors†.10 There was a common belief among Balka n nationalist movements that in order for the Balkan states to move forward successfully, they needed to be united.

Monday, September 23, 2019

Statement of Educational Philosophy Essay Example | Topics and Well Written Essays - 750 words

Statement of Educational Philosophy - Essay Example Even if the best quality seed is sown in bad soil and neglected, it withers away. Edward Joyner of Yale University School said that ‘The development of a tree depends on where it is planted†. The same seed, planted in rich soil, if watered and fertilized and taken care of, sprouts and produced rich and luscious fruit. It is in this way that education of a child is to be perceived. It was John Dewey who compared the child to a plant and the teacher to a gardener. This is especially true of children in the lower school grade. They are delicate in mind and body, extremely sensitive, like soft clay that would take any given shape. The shape that they take in this age is set for their lifetime. There is a need to handle them with gentleness and care. This is not the task of the teacher alone. The entire school atmosphere, the efforts of the team ranging from teachers to directors of the institution, the students and their parents, should all be directed towards the single goal of education. The term ‘education’ here is to be taken in its broadest sense, implying not just providing instruction and information, but the development of social, physical, emotional, intellectual, moral and spiritual aspects, and extending in these times to the ‘global’ aspect. All these aspects are wide and varied, and naturally, cannot be fulfilled in the home setting, among parents and a handful of relatives. The school then, is to be like an expanded home, where experts in every field are appointed to make up for what parents alone cannot do. This does not eliminate the role of parents. Teachers, parents and society should all work together. At the same time, children are the national wealth, future human resource of their country. Hence the government also has an equally important role to play in the system of education. It is up to the lower school director to co-ordinate the efforts of all these elements and harness them for the benefit of stude nts. Another side of the picture is that all students come from different socio-economic backgrounds (almost 7 to 8 strata exist ranging from the very poor to the extremely rich). They have individual differences, different learning capacities, different aims, motivations, aptitudes and inclinations. Some also have physical disabilities. It is difficult but essential to treat them as equal, at the same time, catering to their individual needs. A class should be conducted by two teachers at a time. While one explains, the other can assist with the teaching aids and ppt etc. Later, one of them should conduct separate remedial classes for the weaker students. Simultaneously, the other teacher should go deeper into the same topic with the academically brighter students. In this way, the needs of both groups can be fulfilled. Marva Collins said, that the good teacher makes te poor students good and the good students superior. The school provides a wider and more varied social environment compared to a family. Group projects, team games, co-operative learning methods must be introduced. Socialization of children can be taken care of and maladjustment in future can be prevented. This is extremely important considering the fast and easy means of communication. One or two handicapped children must be placed in each class at least for a couple of sessions. This kind of

Sunday, September 22, 2019

NVQ Business studies Essay Example for Free

NVQ Business studies Essay Diversity should be respected and valued, because nobody is completely the same as anyone else. It is everywhere in our lives which makes rich and varied. In our lives diversity can be defined as differences in heritage, race, beliefs, customs, mental capabilities, physical appearances etc. It should be valued because no one is completely the same as anyone else, even within the above categories. If diversity is not valued then it can lead to violence and hatred. People tend to reject what is different. Our differences/diversities can lead to growth as a society or it can lead to violence and hatred. We must value our diversity in order to work together for the common good of our society/world. ?OCR Business and Administration NVQ (QCF) UNIT 203 Title Work in a business environment Level 2 Credit 2 1. 1Describe what is meant by diversity and why it should be valued? Diversity should be respected and valued, because nobody is completely the same as anyone else. It is everywhere in our lives which makes rich and varied. In our lives diversity can be defined as differences in heritage, race, beliefs, customs, mental capabilities, physical appearances etc. It should be valued because no one is completely the same as anyone else, even within the above categories. If diversity is not valued then it can lead to violence and hatred. People tend to reject what is different. Our differences/diversities can lead to growth as a society or it can lead to violence and hatred. We must value our diversity in order to work together for the common good of our society/world. ?OCR Business and Administration NVQ (QCF) UNIT 203 Title Work in a business environment Level 2 Credit 2 1. 1Describe what is meant by diversity and why it should be valued? Diversity should be respected and valued, because nobody is completely the same as anyone else. It is everywhere in our lives which makes rich and varied. In our lives diversity can be defined as differences in heritage, race, beliefs, customs, mental capabilities, physical appearances etc. It should be valued because no one is completely the same as anyone else, even within the above categories. If diversity is not valued then it can lead to violence and hatred. People tend to reject what is different. Our differences/diversities can lead to growth as a society or it can lead to violence and hatred. We must value our diversity in order to work together for the common good of our society/world. ?OCR Business and Administration NVQ (QCF) UNIT 203 Title Work in a business environment Level 2 Credit 2 1. 1Describe what is meant by diversity and why it should be valued? Diversity should be respected and valued, because nobody is completely the same as anyone else. It is everywhere in our lives which makes rich and varied. In our lives diversity can be defined as differences in heritage, race, beliefs, customs, mental capabilities, physical appearances etc. It should be valued because no one is completely the same as anyone else, even within the above categories. If diversity is not valued then it can lead to violence and hatred. People tend to reject what is different. Our differences/diversities can lead to growth as a society or it can lead to violence and hatred. We must value our diversity in order to work together for the common good of our society/world. ?OCR Business and Administration NVQ (QCF) UNIT 203 Title Work in a business environment Level 2 Credit 2 1. 1Describe what is meant by diversity and why it should be valued? Diversity should be respected and valued, because nobody is completely the same as anyone else. It is everywhere in our lives which makes rich and varied. In our lives diversity can be defined as differences in heritage, race, beliefs, customs, mental capabilities, physical appearances etc. It should be valued because no one is completely the same as anyone else, even within the above categories. If diversity is not valued then it can lead to violence and hatred. People tend to reject what is different. Our differences/diversities can lead to growth as a society or it can lead to violence and hatred. We must value our diversity in order to work together for the common good of our society/world. ?OCR Business and Administration NVQ (QCF) UNIT 203 Title Work in a business environment Level 2 Credit 2 1. 1Describe what is meant by diversity and why it should be valued? Diversity should be respected and valued, because nobody is completely the same as anyone else. It is everywhere in our lives which makes rich and varied. In our lives diversity can be defined as differences in heritage, race, beliefs, customs, mental capabilities, physical appearances etc. It should be valued because no one is completely the same as anyone else, even within the above categories. If diversity is not valued then it can lead to violence and hatred. People tend to reject what is different. Our differences/diversities can lead to growth as a society or it can lead to violence and hatred. We must value our diversity in order to work together for the common good of our society/world. ?OCR Business and Administration NVQ (QCF) UNIT 203 Title Work in a business environment Level 2 Credit 2 1. 1Describe what is meant by diversity and why it should be valued? Diversity should be respected and valued, because nobody is completely the same as anyone else. It is everywhere in our lives which makes rich and varied. In our lives diversity can be defined as differences in heritage, race, beliefs, customs, mental capabilities, physical appearances etc. It should be valued because no one is completely the same as anyone else, even within the above categories. If diversity is not valued then it can lead to violence and hatred. People tend to reject what is different. Our differences/diversities can lead to growth as a society or it can lead to violence and hatred. We must value our diversity in order to work together for the common good of our society/world. ?OCR Business and Administration NVQ (QCF) UNIT 203 Title Work in a business environment Level 2 Credit 2 1. 1Describe what is meant by diversity and why it should be valued? Diversity should be respected and valued, because nobody is completely the same as anyone else. It is everywhere in our lives which makes rich and varied. In our lives diversity can be defined as differences in heritage, race, beliefs, customs, mental capabilities, physical appearances etc. It should be valued because no one is completely the same as anyone else, even within the above categories. If diversity is not valued then it can lead to violence and hatred. People tend to reject what is different. Our differences/diversities can lead to growth as a society or it can lead to violence and hatred. We must value our diversity in order to work together for the common good of our society/world. ?OCR Business and Administration NVQ (QCF) UNIT 203 Title Work in a business environment Level 2 Credit 2 1. 1Describe what is meant by diversity and why it should be valued? Diversity should be respected and valued, because nobody is completely the same as anyone else. It is everywhere in our lives which makes rich and varied. In our lives diversity can be defined as differences in heritage, race, beliefs, customs, mental capabilities, physical appearances etc. It should be valued because no one is completely the same as anyone else, even within the above categories. If diversity is not valued then it can lead to violence and hatred. People tend to reject what is different. Our differences/diversities can lead to growth as a society or it can lead to violence and hatred. We must value our diversity in order to work together for the common good of our society/world. ?OCR Business and Administration NVQ (QCF) UNIT 203 Title Work in a business environment Level 2 Credit 2 1. 1Describe what is meant by diversity and why it should be valued? Diversity should be respected and valued, because nobody is completely the same as anyone else. It is everywhere in our lives which makes rich and varied. In our lives diversity can be defined as differences in heritage, race, beliefs, customs, mental capabilities, physical appearances etc. It should be valued because no one is completely the same as anyone else, even within the above categories. If diversity is not valued then it can lead to violence and hatred. People tend to reject what is different. Our differences/diversities can lead to growth as a society or it can lead to violence and hatred. We must value our diversity in order to work together for the common good of our society/world.

Saturday, September 21, 2019

Political Philosophy and Human Beings Essay Example for Free

Political Philosophy and Human Beings Essay Freedom is generally term we use to talk about politics in our society nowadays. Eudaimonia is not a freedom but it betrays a more general difference in the way Aristotle approaches different societies. Eduaimonia is a biological concept with â€Å"your life going well† With your naturally attributes being fully developed. It is not a matter of your mood. If you ask if someone is flourishing it is more than if they are happy it is are they becoming everything they can be. Are they exercising all of their abilities? Freedom doesn’t have anyting to do with success. Freedoms for Aristotle is part of eudaimonia. Eudaimonia is a collection of goods. You need material things and good luck and freedom and food and water. Pg. 258 Aristotle says eudaimonia is a STATE OF ACTIVITY. VERY IMPORTANT. It is not just well being but also well doing. You’re a Eudaimonistic person only if you enact the activities of a eudaimonistic person. You cant be a good citizen or a happy citizen if you just have rights. You have to exercise these rights. Some kind of activity. Different activities in different cities because different cities have different rules and constitutions. Citizenship is a kind of doing. Citizens have function. The activity of citizens is that which supports the constitution of the city or state or polis which they are apart. The point of the polis is not just living but to have a good life. A good life that combines the success of the individual with the success of a whole. It is always in motion and an activity. Book 3 chapter 9 a polis is not the same thing as an alliance. You cant take any political agreement between 2 or 3 cities and make them one city. Only human beings because they have language Aristotle says can make moral judgments. Not like animals judge where the food is but more complex judgments. Page 10 and 11. Our language is capable of making distinctions that aren’t only physical. Aristotle claims animals don’t make moral judgments. Language and justice are immediately linked to the function of the polis. Our capacity to speak to one another is what makes us political. It is one function of the polis to define good and evil. To come to collective understanding of what is good and what is bad. Human beings have the capacity to debate and judge differently which also means judge badly and judge well. This judging is a kind of activity. It is the business of cities. Even households do in their choosing how to live together. Aristotles discussion of households and cities. Human beings in two principle ways. The member of a lesser whole the household and the member of a larger whole which is the polis Both having ruling parts and ruled parts. Polis Definition of a citizen :one who shares in the administration of justice in the holding of office. He doesn’t say what the office is to incorporate all the states in the Greek world. Some monarchies where people who don’t hold office who are still considered citizens. NOW-A citizen is someone who is a legal candidate for office even if they don’t hold an office at that specific time. Aristotle says if you have that one person who is qualified to be king either you have to make him king or get rid of him. When Aristotle gives the best govt he says different kinds of government are beter for some circumstances. If city is under attack it may be smarter to give control to one person to make all the decisions so there is no confusion. The circumstance of the not so rich not so poor with some allies and some opponents. BEST THING in this situation is to have a middle class that can alternate from ruling and being ruled. He means people who aren’t to rich and aren’t to poor. The poor are to desperate and greedy so they don’t want to consider what is good for everyone. The rich just want to boss everyone around and want charge. The polis is the one compound that can be self-concious about its situation and a ruled and a ruling element. If were ruling we might enjoy it to much so this could be a problem. If we are part of the ruled we might resent being ordered around. Human organization is like animal organization but it also has a special problem and a special solution. The best thing is someone who can understand both ruling and being ruled. That is why the middle class would be best for the position. They understand both sides. Aristotle thinks even in a family they are not totally conscious of their situation. A bee hive has a quen bee but the bee doesn’t know she is in charge and the other bees don’t mind not being in charge it just is what it is. Polity like the Athenian system is best because everyone takes a share in ruling and being ruled. They drew names out of a hat for rule and you were part of ruling if you were pulled in the hat. The city was small enough so over the course of your lifetime almost everyone could be assured to be the ruler of the city. Most of your life you were in the other position of being ruled. This is the best in most condition or the average condition. If one person comes along and seem the best to rule and will give eudaimonia for everyone then they should rule but it happens very rarely. HOUSEHOLD AND SLAVERY The household for Aristotle is another form of social compound like the polis but on a smaller scale. Will have a ruling and a ruled element. Aristotle knows in advance because there is always a ruling and a ruled element he knows what to look for so it is not surprising when he looks in a household he finds these two things. Aristotle’s perspective the adult male in a household rules and everyone else is subordinate to that position. All of the households Aristotle could see were dominated by men and for the most part were slave holding. Some period when individuals are not best in charge of their own lives. (children) Discussion 2/7/14 Aristotle is more concerned with the practical sort of things plato was thinking about how it should be. Aristotle sees the ruler and ruled everywhere. Phone- Sound and voice or pleasure and pain which pertains to animals like a cat screeching or a wolf howling. Logos- is speech and reason and judgment and language. Language and judgment go hand in hand. This is A PART OF BEING HUMAN. 4/10/14 Lecture Notes Hobbes considered by many to be first modern political theorist. Hobbes in politics in conservative for his time and place but his methods are very very radical. HOBBES AND ARISTOTLE Hobbes is opposite of Aristotle. Aristotle learned about politics through observation. He observed nature and looked at how it was replicated towards ourselves. Aristotle thinks all natural beings have a telos which is a natural end. A TELOS is something you are destined for not just death. Hobbes participated in scientific debate when he moved to paris. Attempt like aristotles to approach politics through nature. HOBBES IDEA of what nature is and how you study are so different from aristotles. The state is an artificial animal says hobbes. What you learn about the natural world will not tell you everything and not the most important things about politics and state. The art of man is like the art of god. Look on the political world as a creation but as a human creation making an artificial animal. Study human beings alongside other animals. To Hobbes the state is something radically different from animal congregations and it DOESN’T HAVE TO BE MADE unlike animals. If it is unmade it is chaos and war. Like the England he had to run away from because of civil war. States are not a part of nature. Aristotle says the state is a natural formation and is suppose to be there. For Hobbes this is not true. WHEN HUMAN BEINGS ENTER INTO A STATE NATURE IS WHAT WE LEAVE BEHIND. Human beings were in an unpolitical state before the state which to Hobbes is the state of nature. We were in a previous condition before the state which is nature to hobbes. To Aristotle everything is nature and human beings are always part of the natural world. Aristotles method is human beings are natural and politics and states were natural so he was going around to all different ones to figure out what they had in common. This makes no sense to Hobbes. No state of any kind is natural to Hobbes. Human beings Hobbes says clearly are made by nature and have natural characteristics that human beings have. To Hobbes the people inside the artificial state still have those natural characteristics. You cant leave your body behind to make the state. If states are artificial we can make them how we want. Not aristotles naturally idea of 3-6 types. Hobbes’s theory is sort of liberating but also terrifying. No guarantee we are safe. We are not born into a natural order. If there isn’t an order that we make we wont make it very long. Hobbes’s modern science including distrust of the senses. Hobbes is skeptical of our sensory perception and the ability of our senses to tell us the truth. Sensations clearly come from the natural world but we don’t know exactly where it is coming from. If we know our senses deceive us in some cases we cant be sure they don’t always deceive us. PLATO ALSO DISTRUSTED THE SENSES AND ALSO LIKED GEOMETRY LIKE HOBBES AND EUCLIDIAN GEOMETRY. Plato thinks we can reach some sort of reason and perceive it correctly. Hobbes is not interested in this. Pg. 4(chapter 1) Deviathlon Information we get through introspection can be trusted. Whoever looks into himself and considers what he does when he thinks of reasons hopes and fear. The only way to know humans and to have secure knowledge is to look into yourself. What you find when you look into yourself is good information to everybody else. When I understanding what im doing when I hope then I understand what youre doing when you hope even if they are different hopes. Same thing with fear. THAT FOR HOBBES IS SECURE STARTING POINT FOR SCIENTIFIC KNOWLEDGE TO START POLITICS. Chapter 11-No Telos meaning no teleology don’t study human beings or any part of nature by postulating there is some final ending for them and thinking we can find a way to get them there. Hobbes sees once you get something you want you find something else you want and so on and so on. Like calicles. (from another reading calicles is) Hobbes found this through his own introspection. Hobbes knows his desires are different others but he knows their desire for those things are the same. And he knows that he isn’t satisfied when he gets what he wants so he knows others are the same way. Hobbes doesn’t mean human beings all seek political power but like calicles the power to get what you want. Being able to arrange the world the way you like it. This for hobbes is what is natural. Not a natural ending but a natural beginning. Putting things into motion. Sees it as a physicist. Putting the world into motion. Hobbes says individuals have desires those desires set them in motion and once they are set in motion they don’t tend to stop. Humans are particles seeking what they want with other particles (people) in the way not always getting what we want. Its not just politics to Hobbes that are artificial. Many other things are artificial that aristotles thought was natural. MOST IMPORTANTLY IS SPEECH. (ARISTOTLE SAID SPEECH WAS THE DEFINING NATURAL CHARECTERISITC OF HUMAN BEINGS. HUMANS ARE THE ANIMALS WITH THE NATURAL QUALITY OF SPEAKING AND REASON FOR ARISTOTLE. ) Just about everything except our desires are artificial to Hobbes. Speech is an invention. Hobbes says almost every moral conclusion you want to make you will make it through speech which human beings made up so it doesn’t tell us anything. Chapter 4. All moral truths from Hobbes sense are well constructed senses. We have arranged the terms to lineup. The definition the words line up and make sense so it is true and we can define it. CHAPTER 6- GOOD AND EVIL People disagree not because they make mistakes about reasoning which plato would say they disagree because they have different preferences. They see good and evil through their own preferences. You nor I will worship to persuade each other to what we see fit. What does this mean for politics? Calicles who also thought good and evil were words that people made up. Calicles also thought people were better than others. He thought letting nature work itself out was letting the powerful people dominate the weak. HOBBES THINKS PEOPLE ARE NATURALLY EQUALLY. That doesn’t mean they are equally smart or large or strong or weak. We don’t have equal desires wehave different desires. All Hobbes means by natural equality is that everyone of us is vulnerable to being killed by others. No human being is strong enough by themselves to secure themselves physically to secure themselves from others. WE ARE PHYSICALLY VULNERABLE MOST ESPECIALLY TO ONE ANOTHER. Human beings are born with physical desires and need power and security to help you get your desires. We live in a world with no system we are destined to be apart of like Aristotle thought. We don’t settle our differences by appealing to a natural order or moral principles through reason that plato thought we could all agree on. Moral conceptual political conflicts make the world a dangerous place because if you want catholocism you want it for others not just like chocolate which is for you. Fundamentally human beings are bodies in motion. We will not stop unless we come up against counterveiling force. The state of nature is the war of everyman against everyman. Chaos terror and war. We cannot look to nature to solve our problems because nature is the problem. We are each born with set of desires which are not in agreement with others. THIS IS POLITICAL PROBLEM WHAT IS THE SOLUTION. Reason and justice are just words we need a counter force. Something to bring order to a naturally chaotic system. We need something to make all the particles move in the same direction. The sword signifies the power of the state for Hobbes. There is a solution that has to be imposed just because we are so different. Hobbes understand just how different everyone is and that is a problem. How can you handle the individuality of everyone and make them stop killing eachother when they are left in their natural condition. MUST SET UP A RULE AND GET THEM TO OBEY. We need an incentive that is greater than our natural impulsion of our own desires. Everyone should have their greatest desire being staying alive. So we can enjoy the chocolate or vanilla. We will never enjoy anything in this world unless we are alive. LECTURE 2/12/14 Hobbes In nature there is a lack of agreement, trust and language. Life at the state of nature is solitary or nasty brutish and short to hobbes. The problem is fear and the solution is fear. We fear our own death that is good because then we all know we have that in common. It is rational to want to cooperate with other people but you can be tricked or betrayed. We also fear that other people wont perform their contracts. The solution will have to be some sort of unity. Pg. 132 chapter 17 You want to do whats right and you want to agree with other people but they may not cooperate. If you fear other people the leader will take that fear away and make you fear him. You will know everyone equally fears the sovereign and the consequences for non-agreement so they all have reason to agree. Now you fear death from the sovereign but maybe not as much from other people so now you can make agreements with one another. The sword hangs over all your covenants with one another. No conflilct for hobbes about being afraid and being free. You are in a position to be liberated from the fear of fellow human beings and the state of nature by entering the commonwealth or the artificial state. All you have to do is give up your will to one man or one group of men. Hobbes thinks its more efficient to have one man do it but it can be a group. Where there is disagreement there is distrust and when there is distrust there is violence and war. By all of us agreeing to let one person speak then when he speaks that’s it he has spoken for all of us. Even if we have disagreements it doesn’t matter politically he has spoken and that is it. The existence of the leviathan allows us to make deals and agreements with one another about property etc†¦ We need a form of agreement that ends the problem so we can live in a fundamentally functioning artificial state. We can create an object of mutual equal simultaneous fear. If you can create a state that equally and simultaneously threatens everyone with terrible penalties when they break the law you create the possibility of law which doesn’t exist in the state of nature. It is not a social covenant that protects your rights. It is about a govt protecting your body and your life. Not your rights. You fear govt because it has tremendous power but you are glad it does because it keeps everyone else in line and for yourself you know what to do. If you are a good person in the first place nothing is necessarily being taken away. Yes there is a sword over your head but it brings a situation you wanted anyway. Pg. 170 â€Å"liberty of the subject lies in the silence of the laws† In nature you had the right to anything as far as hobbes was concerned. By placing everybody’s rights in one central place you get back security. Law for hobbes is prohibition. Thou, shall, not kill steal etc†¦ Law and rights are opposite. The more rights you have the less law the more law the less rights. Punishments don’t need to be frequent and laws don’t need to be harsh. Whatever the leviathan does not prohibit you are as free as the state of nature to do what you want to do. The sovereign needs to equally enforce in fear the violation of the law across a wide range of territory. The sovereign does need to be absolute. Pg. 132 ch. 17 – If the sovereign is not absolute the problem is not solved. Without a unity of will the problem isn’t solved that’s why the sovereign needs to make all the laws. Also the sovereign needs to control all doctrines. Leviathan doesn’t care what you think or believe it only cares what you say because it gets them riled up and people think they know whats right which leads them to cause problems. Is it bad to have gov’t control whats printed and distributed? Hobbes thinks its better than civil war. Hobbes thought everyone who had experienced the terror of civil war and everyman against everyman would take the leviathan. The foundation of this is the fact that we all want to live. What threatens leviathan? Competition, diffidence and glory. Diffidence is hobbes word for distrust. Glory and what hobbes sometimes calls vain glory is different because it pertains to a different type of good. Some materially desires can be solved without much difficulty like air and water. If we all want land that is a bit of a problem. We can solve that problem with a law telling us what land we get. It is a clear solution it solves the problem if we have a sword that is good enough. Being famous, being important, being well known, being socially eminent and prominent. Those are things that cannot easily be settled by law. Although laws can help them. Land food water air can be distributed but winning cant be distributed. Only one person can win. Only one person can be prime minister etc†¦ Not everyone can be a movie star because if everyone was nobody would be. Most people are happy with air water and food and land but some people want to be special and these for hobbes are the most dangerous people because some want glory so bad they will risk their lives for it. Some people want what they want even to the point of death. Antigone is someone who cares about something to the point where she is willing to give up her life for it. The antigones to hobbes are the most dangerous people. They are dangerous and make all of us insecure because the point of his threat was not to induce the fear in the law abiding person but to get you to understand everyone else in the state will abide and will be trustworthy. If the threat is not going to deter all then the system is going to break down. That’s what Hobbes thought happened in the English civil war about religion. Leviathan is a plea for rationality. The rational caculation to value your own life above all other things. There is no natural cure for nature. Letting people do their own thing will not turn into some spontaneous social agreement mostly because they cannot trust each other even if it is in both of their interest to do so. A common fear is a sharing experience. You also experience ruling and being ruled at the same time. There is also a sense that the sovereign is all of us. (a bunch of little bodies that make up the leviathan) Hobbes is serious when he says it is a unity. Yes you give up in your rights to the sovereign but you also partake in the sovereign. The sovereign did not exist until you and I agree to give in and make it so. The body of the sovereign is our collective bodies. For hobbes our bodies are what we have in common. We are free to disagree about everything so long as we don’t have a single person to speak for us. The sword is a dictionary or a set of meanings that are legal and illegal not right and wrong. The sword hangs over our head but in our hand we get a dictionary which tells us whit is legal and illegal. Leviathan is also a solution to the moral and linguistic chaos in the state of nature where we don’t agree on anything We can also have freedom and liberty as hobbes understands these terms. Not rights. Rights are what you have to give up to have the practice and experience of liberty. Febraury 19th, 2014 ROUSSEAU – THE SOCIAL CONTRACT Often appointed to a reason for the French Revolution. Pg. 53 on slavery- We are not going to look anymore at gov’t nature but we are going to assume all people are equal in nature. Force can create something but it cant create anything right. If there is going to be something in charge it has to be a covenant. (similar to Hobbes) Gov’t remains with ROUSSEAU something artificial. Rosseau hates hobbes and Aristotle because they are theorists of slavery. Rosseau says there cannot be any such thing as legitimate slavery. If politics isn’t going to have a moral function for Rosseau than it isn’t worth talking or arguing about. Aristotle theorized a natural slavery but for rosseau hobbes theorized an artificial slavery. Slavery under the sovereign. Rosseau says human beings would never consent to slavery by contract. Government has to be by consent and government has to n some sense respect the equality of every person. How to we avoid Hobbes problem of individuals having problems with everyone? Rosseau is not interested in devising a science of politics. Rosseau resembles plato because he wants to work directly in the language of reason. The book is full of historical examples. Comparative lessons on political institutions that have worked in the past. Human beings have a special moral capacity which is another reason why slavery is intolerable to him. HOW IS ROSSEAU GOING TO CREATE A SOCIAL CONTRACT THAT IS MORAL AND IS BASED ON CONSENT? Pg. 60 – if each of us takes individual rights against the state then we will end up back in a state of nature. Rosseau says the only thing that can work is the total alienation of every individual. The alienation of ones rights to the whole community. Hobbes said one gave himself to one man or an assembly of men. A contract that is completely neutral. We are all equal before and after but the nature of our equality has changed. After we are equal beings in this community or new being and we all remain as equal as we are before. The difficulty with this is how does anyone decide what to do. We haven’t solved the problem of how we decide. Pg. 69- beginning of book 2 – If we are going to give everything up to the community rosseau thinks there must be a reason to do it. â€Å"common interest† or the general will. It is not just a series of desires that we happen to share. When there is no love there is no family. Love sustains a family. Even though ‘families’ go through the motions and confide with legal forms there is no love so there is a difference. The general will is to the state what love is to the family. The animating spirit that sustains it and creates and and without it there can be no such thing as a state. Being a member of a family doesn’t mean you don’t have your own opinions or interests that may conflict with other members of the family. But being members with a real loving family there is a time you set those interests and opinions to one side because you care about the fundamental well being of the others in your family so you set those things aside. The development of your reason and your realization of your common interest go together naturally as proto human animals what you lack is not a set of interest but a rational capacity to understand the overlap of your interest with everybody else’s. Our interest don’t change but we realize those interests can be realized beter collectively than they can be singly. The general will exists so long as we continue to believe and support and develop these common interests in the same way the family continues to exist as they believe and support and develop the common view of that family. When you think you are better off without another person it is over even if you go through the motions for a decade after this thought. (likewise for rosseau with a state if we are not committed to them it will not exist even if there is parliament it will be an empty form with no general will. ) Standing behind the social contract is an animated spirit that makes the contract possible but it is only possible for a human being. Animals cannot share in a general will because they don’t have language and cannot reason together. The general will is meant to be at one in the same time a product of reason and a product of some kind of spirit. You cant see it like love in a family you just kind of know that it is there. Rosseau tended to idealize smaller communities. This kind of political community he is proposing is not well suiting for larger states. Rosseau thinks this is what it takes to actually have a state in which people remain free. You do what you need to do because you are happy to be a member of that organization. No one is holding a gun to your head. Even if you are not thrilled to perform the task when you want to do it you understand the non-performance would be letting down your fellows in the community and you don’t want tthat to happen because you value the community and the members in that community. All of us have some communities in which we are willingly apart. The only way a community of equals can be governed is if it is governed by the general will. It will be governed by voting by a community that rosseau imagines. It is very different from majority rule. There is in rosseaus republic majority decision making but not majority rule. The point of the assembly is to discover what the general will is to rosseau. You agree to be bound by the majority because it is the only practical decision role. You go along with the decision of the majority because you think they share the same interest of the common good. When you lose that feeling that you are all there for the common purpose then the state is gone and then you don’t have a good reason to go along with the majority anymore. The shared purpose is gone and you are back to the state of nature where shared individuals have nothing in common. States can fall apart because people don’t have common interest they can also fall apart because there is not constant interaction. Liberty is what you get when you have the general will in place. The general will is not the same thing as love or patriotism but it is similar to it. The spirit that animates you as you act as a citizen as oppose to a private individual.

Friday, September 20, 2019

Stem Cells for Cell Replacement Therapy in Parkinsons

Stem Cells for Cell Replacement Therapy in Parkinsons Stem Cells for Cell Replacement Therapy Said AL Hakmani Introduction Parkinson’s disease is a movement disorder that results from damage to the neurons in the brain that produce the chemical named dopamine. The dopamine sends signals to parts of the brain that controls movement, allowing movement of smooth muscles. In Parkinson’s disease there is loss of the dopamine neurons. Symptoms of the disease include abnormal movement and tremor when a significant amount of dopamine has been lost. It is still not known exactly what causes Parkinson’s disease and the detailed pathophysiology is an area of active research (1, 13). Parkinsons disease is of progressive nature, which implies that it deteriorates with time. But this happens gradually over numerous years. On the other hand, researchers are doing a great deal of exploration to better comprehend what is occurring in the cell. Some studies show that Parkinson disease is associated with an abnormal gene in some individuals, however so far there is insufficient evidence to demonstrate that it’s genetically inherited (1). Braaks hypothesis recommends that Parkinsons disease starts in the digestive tract and in the brain’s centre of smell. The hypothesis is upheld by the way that side effects connected with digestion and smell happen at an early stage of the disease. Professor Jia- Yi Lis research team has now possessed the capacity to tack this methodology further, from the gut to the brain in rat models. The experiment demonstrates how the poisonous protein alpha-synuclein is exchanged starting with one cell, then onto the next before arri ving at the brain’s movement center, leading to the characteristic movement impairment seen in Parkinsons disease. He proves that disease process really can go from the peripheral nervous system to the central nervous system, in this situation from the wall of the gut to the brain (3, 23). Usually people start to have symptoms of Parkinson’s disease between the ages of 50 and 60 years. But in certain cases it starts earlier. The first presenting symptom of Parkinson’s disease is tremor (shaking or trembling). It affect the hands, arms, or legs. It is one of the most common signs, but not everyone has it. Also, not everybody with a tremor has Parkinson’s disease. The tremor often starts only on one side of the body or just one arm or leg. In addition, Parkinson’s disease can cause stiff muscles all through the body, so it causes problems like inconvenience gulping or constipation. In the later phases of Parkinson’s disease a person may have fixed expression, trouble talking and other problems. Some individuals lose mental skills (1, 22). Figure 1 shows the nerve cells in the brain (1) The power of stem cell Stem cells have the potential to develop into various cell sorts in the body during life and schedule growth. In many different tissues they serve as a sort of internal repair system, dividing without limit to replace other cells as long as the animal or person is alive. At the point, when a stem cell divides, every new cell has the capacity either to remain a stem cell or get to be an alternate kind of cell with a more specific function, for example, a red blood cell, a muscle cell, or a brain cell and other cells (5). The stem cells are featured from other cell types by two essential characteristics. First, they are capable of renewing themselves through cell division, frequently after long periods of inactivity. Second, under some physiologic or trail conditions, stem cell can become tissue- or organ-particular cells with special functions. In particular organs, for example, the gut and bone marrow, they consistently separation to repair and supplant exhausted or harmed tissues. Moreover, in diverse organs, for example, the heart and the pancreas, stem cell just partition under exceptional conditions (5, 20). Researchers fundamentally worked with two sorts of undeveloped cells from animals and human: embryonic stem cells and non-embryonic stem cells. Researchers in 1981 found approaches to get embryonic stem cells from early mouse embryos. In 1998 the definite investigation of the science of mouse undifferentiated cells prompted the revelation of human stem cells. However, these cells are called human embryonic stem cells. The embryos utilized in these studies were the result of invitro fertilization strategies for reproductive purposes. When they were no more required for that reason, they were donated for research with the informed consent of the donor (5, 21). Scientists made an alternate achievement by distinguishing conditions that would permit some particular adult cells to be reprogrammed to accept stem cell-like state in 2006. This new sort of stem cell, called induced pluripotent stem cells (iPSCs) (5). These IPS cells may be used in the future to make the patient’s own cells, a safe cell source that is free from other factor which affects the patient. Animal studies in rat and mouse have been carried out to test the possibility of replacing the lost neurons and results have shown that these cells can develop into dopamine neurons. In human studies, it is possible to measure the increase of dopamine neuron function in the striatum of the patient by using positron emission tomography (5). The Stem cells are essential for living organisms for different reasons. In the three to five days old embryos, called a blastocyst, the internal cells give rise to the entire body of the organism, including all of the many specific cell sorts and organs for example, the lungs, heart, skin and other tissues. In certain adult tissues, such as bone marrow, brain, and muscle, the adult stem cells create replacements for cells that are lost through ordinary injury, or disease. The stem cells make new potentials for treating diseases such as heart disease and Parkinson disease. However, much work remains to be carried out in the research facility to understand how to use these cell therapies to treat disease (5).Research on stem cells continues to advance about how can an organism develops from a single cell and how can healthy cells replace damaged cells in adult organisms. The stem cell research is one of the fascinating areas in contemporary biology (5).Many researchers believe that em bryonic stem cell could be an excellent source of dopamine neurons because they can grow in a culture dish and make into any type of cell after long time in culture. Now, the dopamine neurons have been generated from the Human embryonic stem cell. One research study used the special type of companion cell with specific growth factors to promote the differentiation of the embryonic stem cell through several stages into dopamine producing cell (5). Growth of the Human Embryonic Stem Cell To grow the human embryonic stem cell, the cells will grow in the culture dish and will spread and divide on the surface of the media. The culture dish contains the mouse feeder cell which provides the nutrients into the culture media to grow the cell. However, researchers now devised a method to grow the embryonic stem cells without mouse feeder cells to avoid the risk of transfer of viruses from the media to the human (5,6 ,18). The tests used to identify embryonic stem cells in the laboratory are lacking. But, the laboratories that grow the human embryonic stem cells use different types of test such as: Growing and subculture of the stem cell for many months to make sure of the health of the cell. The use of techniques to determine the presence of transcription factors that are produced by undifferentiated cells. There are two important transcription factors Nanog and Oct-4. Both factors help the genes to turn on and off to maintain stem cell undifferentiation and self-renewal (5, 24). Conversion of human ES and iPS cells One study of culture of stem cell found that the effectiveness of PSCs mouse derived DA neurons have shown efficacy in the models of Parkinson Disease. The developing midbrain is characterized by expression of the floor plate (FP) marker FOXA2 and the roof plate marker LMX1A. Canonical WNT signalling is critical for both roof plate function and midbrain DA neuron development. WNT activation incite LMX1A expression and a neurogenic change of PSCs derived midbrain FP towards DA neuron fate. Exposure to CHIR potent GSK3B inhibitor known to strong activate WNT signalling induce LMX1A in FOXA2 and FP precursors. CHIR is more potent than recombinant WNT3A or WNT at inciting LMX1A expression. The efficiency of LMX1A induction depends on the time of CHIR exposure it effect from 3-11 days. Thus, CHIR is the most critical factor for inducing coexpression of FOXA2/LMX1A. FOXA2/LMX1A coexpression require strong expression of SHH signalling using purmorphamine small molecule agonist. Treatment wi th SHH agonist and FGF8 in the absence of CHIR show significant lower expression of FOXA2 by day11 and complete absence of LMX1A expression. An expression of, NGN2, LMX1A and DDC showed establishment of midbrain neuron precursor fate already by day11. Both midbrain FP and DA neuron induction ready to reproduce in independent ES cell and human induced PSCs line. In culture TH positive cells showed coexpression with NURR1 only in FP derived DA neurons coexpressed FXOA2 and LMX1A. Few GABA and serotonin can observe. But, DA level present in culture about eight times higher in FP (9, 12, 15, 19). There are several lines of evidence to demonstrate a crucial role for SMAD signalling during neural induction. Studies in frog identified bone morphogenic protein (BMP) inhibitors, including, follistatin, chordin and noggin as the basic neural affecting factors in the Spemann organizer (10). The drug SB431542 was demonstrated to improve neural prompting in an embryoid body-based hES cell neural induction protocol. SB431542 inhibits the Lefty/Activin/TGFÃŽ ² pathways by blocking phosphorylation of the ALK5, ALK4, and ALK7 receptors. In addition, Noggin or SB431542 treatment improves the neural induction and blockade the SMAD signalling to achieve full neural conversion. The hES cells were exposed for 72 hours to the drug SB431542 or Noggin and observed the growth factor of neural induction was monitored by expression of PAX6 earliest marker of neuroectodermal differentiation. The combined treatment with both Noggin and SB431542 increased the efficiency of neural induction to more than eighty percent of total cells , compared with less than ten percent PAX6 cells when used Noggin or SB431542 alone(10, 17).However, the only PAX6a converts the human embryonic stem cell to neuroectoderm (11, 16). Figure 2: show the model of proposed mechanisms contribute the action of Noggin and SB431542 (10). From the diagram above at the higher density, essentially CNS cells that are PAX6 are formed which are equipped of giving rise to R-NS cells and example capable neuronal populations of motoneurons and dopaminergic neurons inside 19 days of differentiation. While at lower densities both CNS fates and neural crest fates are observed. The neural crest lineages include melanocytes and the neural crest precursor cells amenable to designing and subtype determination reactions (10, 18). In this figure3 shows one research on mice how the people try to make new dopamine. Isolated ventralmidbrain cells were expanded and patterned in vitro before to transfection to overexpress WNTs. The cell phenotype was examined following in the vitro differentiation or transplantation into Parkinsonian mice. Morphogens SHH and FGF8 significant increase the proportion of TH positive spheres out of total spheres compared with FGF2 treatment alone (13). Dopamine Dopamine is a chemical signal that transfers information from one neuron and the next neuron. The receptors found on the cell surface bumps the signals down to the receiving neurons. The dopamine interested in many different important pathways and it found primarily in the mesolimbic pathways which starts with cells in the ventral tegmental area in the midbrain (2).Dopamine plays a number of roles in human and other animals. It controls many functions such as movement, memory, pleasurable reward, attention, sleep, learning, mood, inhibition of prolactin production, and behaviour. The increase and deficiency of this dopamine chemical are the cause of several diseases like Parkinson’ disease. In the brain, part called the basal ganglia controls movement. Basal ganglia thus rely on upon a certain amount of dopamine to function. The action of this occurs by dopamine receptors D 1-5. The deficiency in dopamine in the brain may become delayed and uncoordinated the movement and other function of the body (3). The dopamine is an important neurotransmitter in the brain. Substantial part of the overall dopamine in the body is produced outside the brain by mesenteric organs. The production of dopamine within the central nervous system, depend on the dopamine biosynthesis. There are two steps of dopamine biosynthesis takes place in the cytosol of CAergic neurons and starts with hydroxylase of L-tyrosine at the phenol ring by tyrosine hydroxylase to produce DOPA(4, 14). Figure4 shows the neuronal dopamine metabolism(4). This figure5: show how process of the fibroblasts are taken to culture to induce neural stem cells to make dopamine neurons and transfer to the patient to functional recovery (25). Good Manufacturing Practice There are many challenges to the use of stem cells for replacement therapy. However, the good manufacturing practice (GMP) is a quality assurance system that is used to make sure the product of stem cells is good and safe to use for treatment. The GMP in human embryonic stem cell culture required several components for good clinical practice. First, the culture or the feeder media that use in the laboratory must be reached with standard of GMP. That is why so many are now trying to grow these cells in feeder free conditions. Finally, all components of the culture and cryopreservation media should be validated for use in the GMP system and be non animal derived products (7). The ethical issue surrounding the use of embryonic cell need be carefully controlled. In UK human embryonic stem cell can gathered from left over embryos produced as part of in vitro fertilisation. This can done under strict UK guidelines from Human Fertilisation Embryology Authority (HFEA) and the human tissue authority (HTA) only in the early stage embryos can be used in research up to a maximum of fourteen days of development(8). Conclusion In my conclusion, the development of the research in the recent year will found the treatment of some diseases that affect the human in the neuron system like Parkinson’s disease. In addition, the study of stem cell research may treat disease by transplanted the cell to the body of the human, but the risk factor that makes this study difficult is the potential of the stem cell growth. The study of stem cell factor may solve the problem of cell growth. Also, the feeder that use to make culture is important to grow the cell without any contamination. There are many factors that help the stem cell to grow in the culture dish. These factors make stem cell to grow fast and convert to the different type of tissue organs. Also, there are some inhibitors that inhibited the factors when stem cells are converted to the different sorts. The research on the stem cell still under the process of trail. It is successful to treat some disease, but in other disease is still trying in animal model if it’s successful may try with human, those have Parkinson’s disease.

Thursday, September 19, 2019

Anti-Nepotism and the Loss of Privacy :: Argumentative Persuasive Essays

Anti-Nepotism and the Loss of Privacy Introduction When employees bring their personal problems to work and it affects their performance or the performance of others, clearly you can coach, counsel, warn, and ultimately terminate their employment. In cases where employees did not cause a problem at work but were fired merely because of an anti-nepotism policy, courts in some states found the employees had been discriminated against on the basis of marital status. Such policies penalize employees who are married, as compared to unmarried employees whose relationships are equally intimate. Currently, thirty-eight (38) states prohibit marital status discrimination. Having a more general policy prohibiting employees who co-habit from working in the same area would not violate marital status laws, but could be considered an invasion of common law privacy, which is recognized in most states (Risser 1997). In my paper, I will address the issue of anti-nepotism, and invasion of common law privacy. What business is it of the organization if p eople co-habit? How are employers supposed to know who is living together? The prohibition against invasion of privacy by the government is enforced, yet anti-nepotism policies seem to supercede even those more strictly. Anti-Nepotism What is Nepotism? Nepotism comes about whenever an employee makes decisions affecting a close relative or domestic partner. Included in these decisions are those that pertain to "hiring, appointment, reappointment, classification, reclassification, evaluation, promotion, transfer, discipline, supervision, or pay increases". According to the King County Board of Ethics, nepotism is a conflict of interest based on familial relationship or domestic partnership, and is inconsistent with the basic principles of ethics (Edwards 1998). The practice of nepotism is said to be inconsistent in instances that require impartial decision-making and attempts to ensure that private interest or personal benefit does not override the public’s interest. In addition, nepotism creates situations that appear of improper influence or favor. As such, anti-nepotism policies have been written to protect public organizations from adverse lawsuits. There are many discriminatory clauses of anti-nepotism policies, as they pertain to individual lifestyle and privacy. Although an anti-nepotism policy does not expressly discriminate against an applicant based on the condition of being married or unmarried, it may exclude a person because of the particular identity of his or her spouse. Whether spousal identity – as opposed to marital status per se — is a prohibited basis for discrimination is an unanswered question under many discrimination laws